Abstract
It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome.
Highlights
Implantology, a highly specialized field in dentistry, has rapidly developed the rehabilitation of dentition
[22], the current study examined the different characters
[22], the current study examined thesurface different surfacebetween characters between (Ti-M), Ti-anodizing (Y,Nb)-tetragonal zirconia polycrystal (TZP)
Summary
Implantology, a highly specialized field in dentistry, has rapidly developed the rehabilitation of dentition. Titanium (Ti) is a widely used dental implant material because of its excellent biocompatibility and strength [1]. Its drawback of a visible metallic and grayish color in the esthetically important zone such as the anterior part of the oral cavity has necessitated developing new implant materials that have a similar color of tooth [2]. Zirconia has been introduced as an alternative material that satisfies the criteria of biocompatibility and esthetics, while the associated phenomenon of low strength by low temperature degradation (LTD). The LTD phenomenon in zirconia was substantially reduced by addition of niobium oxide (Nb2 O5 ) [5,6] or tantalum oxide (Ta2 O5 ) [7]. Our previous reports proved that LTD reinforced tetragonal zirconia polycrystal (TZP) discs containing yttria (Y2 O3 ) and niobium oxide (Nb2 O5 ) ((Y,Nb)-TZP) have osteogenic potential similar to that of
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