Abstract
A high mol. wt mucoprotein was extracted with a phenol-water solvent system from human colonic mucosa. It was characterized chemically, physically and immunologically. The mucoprotein was found to consist (based on dry wt) of 50 per cent carbohydrate, N-glycolyl neuraminic acid, fucose, galactose, galactosamine and glucosamine present in the molar ratios 19:10:26:23:23 respectively, and 40 per cent protein. Amino acid composition was characterized by a high percentage of threonine, serine, proline, glycine and glutamic acid. The material has the interesting property of binding certain small molecules such as RNA, albumin and certain cations, the binding being reversible at high ionic strengths. It was found to be antigenic in rabbits and antigenically non-cross reactive with either CEA or the blood group substances. Its possible physiologic role and its importance in certain disease states is considered.
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