Abstract
High-intensity focused ultrasound system (Image Guided Therapy, Pessac France) with magnetic resonance guidance was developed and used for evaluation of thermal and mechanical ablation methods in mouse tumors. The system comprises a 3 MHz annular array transducer (48 mm diameter and 35 mm radius of curvature) consisting of 16 elements that allow moving the focus electronically along the transducer axis. Experimental characterization of nonlinear acoustic field generated by such high-frequency strongly focused transducer is technically challenging because of the fine spatial structure of the field, small dimensions of the focal lobe, and limited hydrophone bandwidth. Here we evaluated pressure levels and shock-forming conditions for the system using a combination of numerical modeling based on the 3D Westervelt equation with holographic boundary condition obtained from low-power measurements. The holograms were measured separately for each element and combined together to obtain a boundary condition for th...
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