Abstract
A single intravenous injection of 1 ml freshly heparinized donor blood given 7 days prior to transplantation prolonged significantly the survival of subsequent hepatic allografts in fully allogeneic ACI(RT1 a)-to-LEW(RT1 1) rats. The cellular identity of allograft infiltrates was investigated at various times after transplantation using OX8 (CD8) and W3/25 (CD4) monoclonal antibodies. The number of CD8 + cells increased rapidly and reached a peak on Day 3 after transplantation of the untreated allografts. Similarly, the number of CD8 + cells in the allografts from DST-treated rats was maximum on Day 3 and decreased gradually thereafter. The maximum number of CD4 + cells was found on Day 3 in untreated allografts. In contrast, no significant infiltration of CD4 + cells occurred during the first 7 days after transplantation in DST-treated allografts. Thereafter, the number of CD4 + cells increased rapidly and reached a peak on Day 14. CD4 + cells remained persistently elevated in hepatic allografts of rats pretreated with DST, but did not become functionally competent or initiate rejection. These findings suggest that persistent infiltration by CD4 + cells is a characteristic feature of long-surviving hepatic allografts in rats pretreated with DST.
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