Abstract
A method for the determination of the molecular weight distribution of heparins using heparin oligosaccharides as calibration standards and high-performance size exclusion liquid chromatography has been developed. An organic microparticulate stationary phase (TSK 3000), an aqueous mobile phase and UV detection at 206 nm were adopted. Commercial heparins, low-molecular-weight heparins and polysulphated mucopolysaccharides with heparin-like activities were characterized by this procedure. Average molecular weights [weight average ( M w ), number average ( M n ), z average ( M z )] and molecular weight distribution (cumulative weight fraction and differential weight fraction) were calculated from the chromatographic data.
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