Abstract
The glycosaminoglycans were isolated from polymorphs and monocytes which were induced in peritoneal cavity of guinea pig by the injection of caseinate solution. The glycosaminoglycan contents of polymorphs and monocytes were approximately 25 and 47 μg of glucuronic acid per 100 mg of dry weight, respectively. The compositions of glycosaminoglycans in polymorphs and monocytes were different from each other. Electrophoretic characterization and enzymatic susceptibility demonstrated that the glycosaminoglycans in polymorphs contained hyaluronic acid as the main constituent with minor components of other glycosaminoglycans and that the major glycosaminoglycan in monocytes was dermatan sulfate. Polymorphs and monocytes were incubated in vitro in the presence of labeled precursor. The results indicated that chondroitin sulfate and dermatan sulfate in polymorphs were synthesized by incubation in vitro at the ratio of 60–65 and 30%, respectively, and that monocytes synthesized 20% of chondroitin sulfate and 70% of dermatan sulfate.
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