Abstract
The intrinsic dissolution is a test which has been used for many years for the characterization of solid drug. This study aimed to characterize the antiretroviral drug efavirenz from the intrinsic dissolution and compared to the biopharmaceutical classification system (BCS). Initially, was prepared a calibration curve with 5 points read at wavelength of 247 nm in order to analyze the concentration of the samples. For the formation of the tablet was used 20 mg of the drug under pressure of 2 tons for 1 minute. Then, the test was carried out intrinsic dissolution in the middle sodium lauryl sulphate 0.5% at 37 ° C under agitation of 50 rpm. By analyzing the data obtained, it was observed that the calibration curve was linear with r = 0.9998. Regarding the intrinsic dissolution rate (VDI), this was equal to 0.0058 mg/ml/min corroborating the SBC is a drug of low water solubility. Thus, by having more controlled conditions the intrinsic dissolution has become evidence for the purpose of being employed in the SBC and is used for characterization of pharmaceuticals.
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