Abstract
Solid-state DNA was investigated for mass-based detection of common volatile organic compounds (VOCs) with a quartz crystal microbalance (QCM). Acoustically thin coatings of DNA films produced gravimetric vapor sorption responses with selectivity and response speeds comparable to conventional synthetic polymer coatings. Short-sequence single-strand DNA oligonucleotides exhibit amphiphilic sorption properties, responding to both polar and non-polar organic vapors. In the vapor concentration range p/p0<0.06, sensor response is linear. Sensors have selective responses that are dependent on oligomer composition, sequence length, and salting conditions. QCM-derived equilibrium constants were analyzed by linear solvation energy relationships (LSER) for 20 vapors with a broad range of chemical properties, showing differences between DNA oligomers related to composition. Secondary structure effects were not discernable from the vapor sorption data, but LSER properties provide a reference point for understanding DNA as a vapor sorption material.
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