Abstract
Spontaneous diabetes mellitus has been studied inMystromys albicaudatus (South African hamster) at the University of Missouri, Columbia Medical Center since its original discovery here in 1969. Thus far, characteristics established as part of the diabetic syndrome in this species included hyperglycemia, glucosuria, ketonuria, polyuria, polyphagia and polydipsia with variations in age of onset, degree of severity, and rate of progression. In addition, decreased glucose tolerance has been demonstrated and statistical analyses of data collected indicated that diabetes mellitus inM. albicaudatus has a polygenic, nonsex-linked mode of inheritance. — Histologic findings involving the pancreas, kidneys, and liver were found to be positively correlated to diagnostic parameters as well as to their degree of severity and duration. Pancreatic lesions includedΒ-cell vacuolization, glycogen infiltration, nuclear pyknosis, margination of organelles, andΒ-cell death.
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