Characterization of Defectiveness of Human Adenoviruses in Green Monkey Kidney Cells.

Abstract

SummaryIn the absence of foreign helper viruses, human adenoviruses are defective in simian cells, but the degree of effectiveness varies with the adenovirus. Adenovirus 2 initiates an infection in the simian cells but there is no increase in virus titer. When simian cells are infected with adenovirus 7, a small amount of infectious virus is produced but the amount never exceeds the input level. Each cell in the population produces a small amount of virus. The increase in infectious virus is dependent upon DNA synthesis. The simian cells therefore appear to be “leaky” for some human adenovirus serotypes.