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Abstract
Repeated passage of undiluted pseudorabies virus in rabbit kidney cells resulted in a decrease in the yield of infectious virus; by passage 49 (Pr-49) the titer was reduced by approximately 99%. The lower yields of infectious virus produced by the cells are due to interference by defective viral particles which possess sedimentation and antigenic properties similar to those of standard pseudorabies virions. The viral DNA synthesized by cells infected with Pr-49 virus and the DNA encapsidated into particles produced by these cells have a lower buoyant density in CsCl than does the DNA of standard Pr virus. This DNA contains viral DNA sequences with varying degrees of reiteration frequencies. Cellular DNA sequences could not be detected in Pr-49 viral DNA.
Published Version
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