Abstract
Characterization of Darunavir: Β-Cyclodextrin complex and Comparison with the Forms of Darunavir Ethanolate and Hydrate Darunavir, a protease inhibitor used in the treatment of HIV infection, presents solubility problems and so it was complexed with β-cyclodextrin. Complexation increased the solubility of the drug in more than 28 times compared to the free drug. Then, it is important to characterize this recent advance of pharmaceutical technology as well as its comparison with the forms of free darunavir, hydrate and ethanolate. Spectroscopy in the infrared (IR), thermal techniques of thermogravimetry (TG) and differential scanning calorimetry with heat flux (DSC) and X-ray powder diffraction were elected for the characterization of darunavir:β-cyclodextrin complex and comparison with darunavir ethanolate and darunavir hydrate.
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