Abstract
Background Cancer is the second leading cause of death worldwide, and oral cancer ranks tenth among all types [1]. Chemotherapy, radiotherapy and surgery are current therapeutic options; however these are not fully efficient. Permanent functional impairment and aesthetic scars are frequent [2]. In this scenario, it is crucial to find therapeutic alternatives, including those derived from the flora, which currently provides about 1/3 of all new medicines. Anacardic acids, cardanols and cardols are the main constituents of the cashew nut shell liquid (herein referred to as “LCC”) and together, account for 90% of its composition. The liquid is an industrial byproduct, with low economic value prior to processing. The nut, the proper fruit from the plant Anacardium occidentale, is edible. Anacardic acids, cardols and cardanols are made of a phenolic ring connected to a long side chain (usually C15H31-n) that can bear several to none insaturations. Additionally, a methyl group can be found in the phenolic ring [3]. Apart from current industrial uses, it has been demonstrated that some of these compounds may exert microbicide and antioxidative activities. Anacardic acid has been shown to be cytotoxic to lung, liver and gastric tumor cells through epigenetic mechanisms by inhibiting histone acetyltransferases (HATs) [4] and in a capase-independent manner [5]. However, given the possible molecular diversity obtained from LCC constituents, not all distinct LCC derivatives have yet been fully analyzed or characterized. Aim The aim of the present study was to screen for compounds with cytotoxic activity in oral cancer cells and characterize the observed effect.
Highlights
Cancer is the second leading cause of death worldwide, and oral cancer ranks tenth among all types [1]
Aim The aim of the present study was to screen for compounds with cytotoxic activity in oral cancer cells and characterize the observed effect
Citotoxicity and cell viability were measured by spectrophotometry and crystal violet assays
Summary
Cancer is the second leading cause of death worldwide, and oral cancer ranks tenth among all types [1]. Chemotherapy, radiotherapy and surgery are current therapeutic options; these are not fully efficient. Permanent functional impairment and aesthetic scars are frequent [2]. In this scenario, it is crucial to find therapeutic alternatives, including those derived from the flora, which currently provides about 1/3 of all new medicines. Cardanols and cardols are the main constituents of the cashew nut shell liquid ( referred to as “LCC”) and together, account for 90% of its composition. Cardols and cardanols are made of a phenolic ring connected to a long side chain (usually C15H31-n) that can bear several to none insaturations. Given the possible molecular diversity obtained from LCC constituents, not all distinct LCC derivatives have yet been fully analyzed or characterized
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
