Abstract
The aims of this study were to characterize the curcumin/cyclodextrin polymer inclusion complex using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and UV–vis spectroscopy, and to determine the antioxidant activity of this complex by methods of scavenging 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals assays and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals assays. The inhibitory effect of inclusion complex on A375 cells was also investigated by CCK-8 assay, Annexin-V/PI staining assay, and caspase activity assay. The results showed that the complex exhibited different physicochemical characteristics from that of free curcumin. Moreover, the inclusion complex exhibited novel antioxidant activity by scavenging the ABTS and DPPH free radicals and displayed higher antiproliferative activity on A375 cells. Further investigation revealed that inclusion complex could induce A375 cell apoptosis. These findings suggest that inclusion complex could be developed as a novel natural antioxidant with potential applications in cancer chemoprevention.
Highlights
Curcumin (C21 H20 O6 ), a hydrophobic yellow-orange polyphenol derived from the rhizome of the herb Curcuma longa, has been widely used in food as a stabilizer in jellies or as a natural colorant in cheeses and in traditional medicine as an ingredient [1,2]
8.78, 9.86 11.99, 13.76, 15.79, 17.13, and 21.01 were present in the X-ray diffractogram of curcumin curcumin powder, suggesting that the powder exists in a crystalline form
The X-ray diffractometry (XRD) pattern of powder, suggesting that the powder exists in a crystalline form
Summary
Curcumin (C21 H20 O6 ), a hydrophobic yellow-orange polyphenol derived from the rhizome of the herb Curcuma longa, has been widely used in food as a stabilizer in jellies or as a natural colorant in cheeses and in traditional medicine as an ingredient [1,2]. The disadvantage of poor bioavailability and rapid metabolism of curcumin has restricted its application. Various techniques such as liposomes, nanocapsules, nanoparticles, and various derivatives of cyclodextrins have been tried to enhance curcumin delivery [5]. Among these methods, inclusion complexation with cyclodextrins and their derivatives are the most useful method to enhance the aqueous solubility of poorly water-soluble bioproducts [6]. Many studies on enhancement of solubility of curcumin with cyclodextrins have been reported.
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