Abstract
Monodispersed, highly crystalline dendrimer-stabilized gold nanoparticles (Au DSNPs)were synthesized via hydrazine reduction chemistry and stabilized using primaryamine-terminated poly(amidoamine) (PAMAM) dendrimers of different generations(generations 2–6) with the same molar ratios of dendrimer terminal nitrogen ligands/goldatoms. The sizes of the synthesized Au DSNPs decrease with the increase of the number ofdendrimer generations. These Au DSNPs are fluorescent and display strong blue emissionintensity at 458 nm. Polyacrylamide gel electrophoresis (PAGE) analysis indicates that allAu DSNPs are stable and both metal NPs and dendrimer stabilizers do not separate fromeach other during the electrophoresis process. The synthesized inorganic/organic hybrid AuDSNPs provide new nanoplatforms that will be further modified with variousbiological ligands for the application of biosensing and targeted cancer therapeutics.
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