Characterization of Cortical Networks and Corticocortical Functional Connectivity Mediating Arbitrary Visuomotor Mapping.

Abstract

In everyday life, most of our behaviors are based on the arbitrary linkage of sensory information to actions and goals, such as stopping at a red traffic light. Despite their automaticity, such behaviors rely on the activity of a large brain network and elusive interareal functional connectivity. We take a novel approach exploiting noninvasive recordings of human brain activity to reveal the cortical networks and corticocortical functional connectivity mediating visuomotor mappings. Parietal areas were found to play a driving role in the network, whereas premotor areas acted as relays from parietal to medial prefrontal cortices, which played a receiving role. Overall, our approach and results provide novel perspectives toward a better understanding of how distributed brain activity coordinates adaptive behaviors.