Abstract
The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms.
Highlights
Fluoroquinolones are representatives of an important group of chemotherapeutic compounds with a broad spectrum of activity against various pathogenic microorganisms resistant to aminoglycosides, penicillins, cephalosporins, tetracyclines and other antibiotics
It has been suggested that metal complex intermediates participate in this process [3] in such a way that in the presence of metal ions, the uptake of quinolones by the bacterial cells is higher in comparison with the drugs acting alone
This paper presents the process of developing a new, wound healing, antibacterial dressing loaded with a ciprofloxacin-bismuth complex and its characterization, performed with the use of several analytical and microbiological methods
Summary
Fluoroquinolones are representatives of an important group of chemotherapeutic compounds with a broad spectrum of activity against various pathogenic microorganisms resistant to aminoglycosides, penicillins, cephalosporins, tetracyclines and other antibiotics. They exhibit activity against aerobic Gram-negative and Gram-positive bacteria, while they are especially active against the aminoglycoside-resistant Pseudomonas aeruginosa and beta-lactamase-producing organisms [1]. Combining metals with pharmaceutical agents can provide a strategy to improve drugs’ activity, decrease their toxicity and overcome resistance to their action Quinolones, due to their ability to coordinate metal ions, may find a interesting application in this strategy [5].
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