Abstract
A simple and effective modification of the working screen printed carbon electrode (SPCE)surface has been developed with a mixture of chitosan biopolymer and nano cerium oxide at 1:1 compositionfor the detection of melatonin, a circadian rhythm regulation hormone. The fabricated electrode wascharacterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrophotometer (EDS),electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Electro-oxidation behaviors ofmelatonin were extensively observed by differential pulse voltammetric(DPV) analysis. The experimentalresults demonstrated that the modified cerium oxide-chitosan screen printed carbon electrode (SPCE-Chi-CeO2) exhibited satisfactorily improvement in the electrochemical current sensitivity.Alinear calibrationcurve for melatonin was obtained in the concentration range from 0-10 µg/ml with a detection limit of 0.18µg/ml based on DPV measurement. Good selectivity was also obtained in an interference study with someother closely structural related compounds such as tryptophan and serotonin. Thus this modification strategywas proved to be a suitable tool for the simple, fast, sensitive and selective determination of melatonin.
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