Characterization of Ca 3SiO 5/CaCl 2 composite cement for dental application

Abstract

Objectives The purpose of this study was to investigate the effect of CaCl 2 on the setting time, pH values and compressive strength of tricalcium silicate, and the in vitro bioactivity and compatibility of Ca 3SiO 5/CaCl 2 composite paste was also studied to explore the possibility for using as a root canal filling material. Methods Composite cements were obtained by mixing Ca 3SiO 5 and different amounts of CaCl 2 (0, 5%, 10% and 15%) with deionized water as liquid phase. The composite cement and pure tricalcium silicate were compared for setting time, pH value, compressive strength, in vitro bioactivity and compatibility. Results With the addition of CaCl 2 from 0% to 15%, the initial setting time and final setting time decreased obviously from 90 to 50 min and from 180 to 90 min, respectively. The compressive strength of the Ca 3SiO 5/CaCl 2 composite cement after setting for 7 days increased obviously from 5.28 to 23.46 MPa when the content of CaCl 2 increased from 0% to 10%. Furthermore, the paste with up to 15% of CaCl 2 showed good ability to induce the formation of hydroxyapatite (HA), and the dissolution extracts of the Ca 3SiO 5/CaCl 2 composite paste also have a stimulatory effect on L929 cell proliferation in a certain concentration range. Significance The results indicated that the Ca 3SiO 5/CaCl 2 composite cement had good self-setting properties, bioactivity and compatibility, and may be used as a novel root canal filling material.