Abstract
BackgroundIn this study, the biocompatibility, stability and osteotransductivity of a new cement based on alpha-tricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model.MethodsThe potential of alpha-TCP on bone repair was compared to autogenous bone grafting, and unfilled cavities were used as negative control. Surgical cavities were prepared and designated as test (T), implanted with alpha-TCP blocks; negative control (C - ), unfilled; and positive control (C + ), implanted with autogenous bone graft. Results were analyzed on postoperative days three, seven, 14, 21 and 60.ResultsThe histological analyses showed the following results. Postoperative day three: presence of inflammatory infiltrate, erythrocytes and proliferating fibroblasts in T, C - and C + samples. Day seven: extensive bone neoformation in groups T and C + , and beginning of alpha-TCP resorption by phagocytic cells. Days 14 and 21: osteoblastic activity in the three types of cavities. Day 60: In all samples, neoformed bone similar to surrounding bone. Moderate interruption on the ostectomized cortical bone.ConclusionsBone neoformation is seen seven days after implantation of alpha-TCP and autogenous bone. Comparison of C - with T and C + samples showed that repair is faster in implanted cavities; on day 60, control groups presented almost complete bone repair. Alpha-TCP cement presents biocompatibility and osteotransductivity, besides stability, but 60 days after surgery the cavities were not closed.
Highlights
In this study, the biocompatibility, stability and osteotransductivity of a new cement based on alphatricalcium phosphate were investigated in a bone repair model using a rat model
Autogenous bone graft is considered to be the gold standard for replacement of lost tissue [3,4]
In 1999 [5], defined the three processes associated to the fate of bone grafts: osteogenesis, osteoinduction and osteoconduction
Summary
The biocompatibility, stability and osteotransductivity of a new cement based on alphatricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model. Bone repair occurs in a process that may take months or years [2]. The morphological and functional recovery of hard tissues lost during the treatment of pathological processes and traumatic lesions has been extensively studied, and different approaches have been suggested. Autogenous bone graft is considered to be the gold standard for replacement of lost tissue [3,4]. In 1999 [5], defined the three processes associated to the fate of bone grafts: osteogenesis, osteoinduction and osteoconduction. Osteogenesis is formation of bone, whereas osteoinduction is the process by which osteogenesis is induced and osteoconduction is a physiologic
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