Characterization of binding sites for two classes of calcium channel antagonists in human forebrain

Abstract

1,4-Dihydropyridine ([ 3H]PN200-110) and phenylalkylamine ([ 3H](−)D-888) bound with high affinity to human brain cortex homogenates. The ligand selectivity pattern indicates that [ 3H]PN200-110 binding was inhibited by related 1,4-dihydropyridine analogues but not phenylalkylamines. On the other hand, phenylalkylamines were potent inhibitors of [ 3H](−)D-888 binding in human brain. The radioautographic distribution of [ 3H]PN200-110 and [ 3H](−)D-888 binding sites demonstrates that 1,4-dihydropyridine and phenylalkylamine sites were similarly distributed in human forebrain.