Abstract
It has been very difficult to develop and evaluate efficient fish vaccines because fish immune cells have not been properly characterized. In this study, we investigated the cell‐mediated immunological properties of B‐ and T‐like cells in Nile tilapia (Oreochromis nilotica). Surface immunoglobulin negative (slg‐) cell population proliferated in response to mammalian T‐cell mitogens PHA and Con A, while surface immuno globulin positive (slg+) cells responded to the B‐cell mitogen LPS. The sIg‐ cells from hemocyanin (HC)‐immunized Tilapia, compared to the non‐immunized control, reacted more to PHA than to Con A. Unexpectedly, antigen (Ag)‐specific response was observed in both sIg‐ and sIg+ cells. Regardless of HC immunization, whole leukocytes from a head kidney of fish showed natural killer (NK) cell activity. Especially, NK cell activity was much higher in sIg‐ cells than in sIg+ cells, indicating the possibility that fish NK cells were not at least associated with sIg+ cell population and not activated ...
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