Abstract
We synthesized peptide-resin conjugates (1 and 2) by immobilizing <TEX>${\beta}$</TEX>-sheet antibacterial peptide and <TEX>${\alpha}$</TEX> helical antibacterial peptide on PEG-PS resin, respectively. Conjugate 1 showed considerable antibacterial activity in various conditions, whereas conjugate 2 did not exhibit antibacterial activity. The growths of various bacteria were inhibited by conjugate 1 even at lower concentrations than MIC. Conjugate 1 killed bacteria at MIC and had a potent synergistic effect with current antibacterial agents such as vancomycin and tetracycline, respectively. Overall results indicate that polymer surface modification using antibacterial <TEX>${\beta}$</TEX> sheet peptide is a powerful way to prevent microbial contamination on polymer surfaces.
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