Abstract
Background Surveillance of resistance to antimalarials is a priority in the light of limited therapeutic options against P. falciparum and the emergence of artemisinin resistant strains. In some countries, antifolates and 4-aminoquinolines might remain a second line choice therapy, mainly in particular clinical situations or when availability of artemisinin combined therapy (ACT) is limited. During the past decade, we have monitored the status of antimalarial resistance associated genes in the northwest region of Colombia, where both vivax and falciparum malaria are highly endemic. Treatment for P. falciparum infection in Colombia is based on ACT, and for P. vivax, on choloroquine plus primaquine. Some authors have reported pregnant subjects as an important reservoir of P. falciparum resistant clones, mainly as a consequence of Intermittent preventive treatment in pregnancy (IPTp). In the light of the recent reports made in Colombia of a higher than expected frequency of pregnancy associated malaria, efforts were directed to study the genetic characteristics of the P. falciparum and P. vivax alleles associated with antifolate resistance in pregnant and non-pregnant populations of the country.
Highlights
Surveillance of resistance to antimalarials is a priority in the light of limited therapeutic options against P. falciparum and the emergence of artemisinin resistant strains
Treatment for P. falciparum infection in Colombia is based on artemisinin combined therapy (ACT), and for P. vivax, on choloroquine plus primaquine
In the light of the recent reports made in Colombia of a higher than expected frequency of pregnancy associated malaria, efforts were directed to study the genetic characteristics of the P. falciparum and P. vivax alleles associated with antifolate resistance in pregnant and non-pregnant populations of the country
Summary
Surveillance of resistance to antimalarials is a priority in the light of limited therapeutic options against P. falciparum and the emergence of artemisinin resistant strains. Antifolates and 4-aminoquinolines might remain a second line choice therapy, mainly in particular clinical situations or when availability of artemisinin combined therapy (ACT) is limited. Treatment for P. falciparum infection in Colombia is based on ACT, and for P. vivax, on choloroquine plus primaquine. Some authors have reported pregnant subjects as an important reservoir of P. falciparum resistant clones, mainly as a consequence of Intermittent preventive treatment in pregnancy (IPTp). In the light of the recent reports made in Colombia of a higher than expected frequency of pregnancy associated malaria, efforts were directed to study the genetic characteristics of the P. falciparum and P. vivax alleles associated with antifolate resistance in pregnant and non-pregnant populations of the country
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