Abstract
Upon Injury, a complex biological response of tissues is initiated to protect the organism and remove the injurious stimuli then trigger the healing process. Inflammation is a part of this complex response. The local response to tissue injury or infection is acute inflammation. Without inflammation, wounds and infections would never heal. This response is called the acute-phase response. After the beginning of inflammation, a large number of changes in the physiological system occur and last for 1 or 2 days; the system then returns to normal for 4 to 7 days provided there is no further stimulation. This systemic response is called acutephase reaction (APR), also called acute-phase response. APR is characterized by fever and by an increased number of peripheral white blood cells. At the same time, cellular and biochemical changes occur in liver or other cells. One of the important events in acute-phase response is the change of the protein molecules in the plasma, known as the acute-phase proteins (APPs) (1–6).
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