Abstract
An oxytocic fraction has been isolated from pituitaries of the ratfish ( Hydrolagus colliei) with pharmacological properties that differ from those of all known naturally occurring neurohypophysial principles except oxytocin. When subjected to partition column chromatography on Sephadex the Hydrolagus fraction appears to be a single peptide. Its mobilities on such columns are the same as those of oxytocin. If this principle is oxytocin its presence in the ratfish raises new questions concerning the manner in which neurohypophysial peptides have changed during the course of vertebrate evolution.
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