Characterization of a novel marker of oxidative stress in men from 774 infertile couples

Abstract

Oxidative stress damage is thought to occur through the high formation of adducts, molecules of lipids, DNA, and protein in semen that have been covalently modified by reactive oxygen species (ROS). The oxidative stress adduct (OSA) test, a novel biomarker assay, directly quantifies ROS damage by measuring the levels of molecules in semen covalently modified by ROS. The goal of this study is to characterize OSA scores in a large number of men from infertile couples.