Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale‐up for high content screening

Abstract

In the discussion section (page 477), the paragraph shown below was a duplication of text in the previous paragraph and should be disregarded. “The identification of drugs and appropriate targets for normalization of defective vasculature might be of medical importance not only for vascular disease but also for adjunctive tumour therapy. Defective vasculature has been considered a potential reason for poor delivery of antitumour drugs to within solid tumours, and inhibition of angiogenesis has been suggested to hinder drug delivery and promote cancer cell selection towards higher malignancy and metastatic potential (Paez-Ribes et al., 2009). Thus the approach of promoting or normalizing vasculature, instead of inhibiting tumour vasculogenesis, may prove to be a more helpful strategy by allowing more efficient delivery of chemotherapy drugs (reviewed by Jain, 2005). Thus our experimental results should enable HCS assays based on functional vessel formation that may lead to drugs that normalize defective vasculature.”