Abstract
A cold-sensitive mutant of Salmonella typhimurium LT2 that grows at 37 C but not at 20 C has altered repression regulation in at least two amino acid biosynthetic pathways (histidine and isoleucine). The lesion conferring cold sensitivity that is linked with hisW is recessive. Assays for the acceptance of some amino acids by transfer ribonucleic acid (tRNA) reveal a decreased ability of the mutant tRNA to accept arginine, phenylalanine, and histidine. A mutation in a gene for tRNA maturation is a likely possibility for the mutation producing these effects on growth, regulation, and amino acid acceptance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
