Abstract
The novel benzodiazepine tifluadom was compared with a selection of proposed μ- and k-opiate agonists using a combined heat/ pressure nociceptive paradigm. Calculation of the relative potency ratios to the nociceptive stimuli revealed a distinction between μ-and k-agonists. The potency ratio yielded by tifluadom coincided with that displayed by the k-agonists and this finding is discussed in relation to morphine withdrawal and radioligand binding studies.
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