Characterization of (16 R) and (16 S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343

Laird A Trimble,Mark W Sumarah,Barbara A Blackwell,Mark D Wrona,J David Miller

doi:10.1016/j.tetlet.2011.12.052

Characterization of (16 R) and (16 S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343

Laird A Trimble, Mark W Sumarah + Show 3 more

https://doi.org/10.1016/j.tetlet.2011.12.052

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Journal: Tetrahedron Letters	Publication Date: Dec 27, 2011
Citations: 10

Affiliation: MSD (Canada), Carleton University, Agriculture and Agri-Food Canada

#Diastereomeric Metabolites #LC NMR + Show 2 more

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Abstract

Two diastereomeric metabolites (16 R) and (16 S)-hydroxyroquefortine C were characterized from Penicillium crustosum DAOM 215343. The 16 S metabolite is reported for the first time along with evidence for the absolute stereochemistry of both. The metabolites were originally detected by LC–NMR and the structures of the subsequently isolated metabolites were elucidated by HRMS and NMR.

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