Abstract

The role of moisture in the compactibility of β-cyclodextrin has been examined. A physically modified β-cyclodextrin (BCD-DC) was compared to a commercial β-cyclodextrin product (Kleptose®). The moisture sorption-desorption isotherms of both β-cyclodextrin samples showed considerable hysteresis. This can be attributed to the fact that water is associated to β-cyclodextrin in the form of a crystal hydrate. Both β-cyclodextrin samples lost their compactibility on removal of water, thus demonstrating that moisture is essential for the compactibility of β-cyclodextrin. A moisture content of about 14% appears to be optimum for maximum compactibility of samples studied.

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