Abstract
1. 1. The pancreatic stone protein (PSP, M r 15,000) which has been discovered in human calculi derives from the native glycosylated forms of the protein ( M s s 17,500–22,000) which are present in human pancreatic juice through tryptic cleavage of the Arg 11-Ile 12 bond. 2. 2. In the present study, a homologous native form of the protein ( M r 17,000) was purified from rat pancreatic juice. 3. 3. Its N- terminal amino acid sequence was found to display a high degree of homology with that of the human native protein forms, apart from the fact that it was not glycosylated. 4. 4. In rat as in human, tryptic cleavage of the Arg 11-Ile 12 bond transforms a soluble protein into one which is practically insoluble at neutral pH.
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