Abstract
Sulfonylation of the 5-styryl-2-aminochalcones with p-toluenesulfonyl chloride in pyridine afforded novel 5-styryl-2-sulfonamidochalcone hybrids. XRD analysis of a representative compound helped to confirm the presence of a six-membered N–H···O intramolecularly hydrogen bonded chair-like pseudo ring. Topology was determined through Hirshfeld surface analysis and the energy of frontier molecular orbitals was used to evaluate the stability of this compound. The inhibitory effect of the test compounds against α-glucosidase and α-amylase activities was evaluated in vitro through enzymatic assays, and their antioxidant properties also in vitro through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging assays. An in vitro cell-based antioxidant activity assay of the most active compounds, 2f and 2h, involving lipopolysaccharide (LPS) induced reactive oxygen species (ROS) production also confirmed their capability to scavenge free radicals. Molecular modelling was used to postulate ligand–enzyme interactions and to rationalize the mechanism of antioxidant effect of these compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
