Abstract
The molecular mechanisms involved in the control of gonadotropin releasing hormone gene expression are largely unknown in humans. Although it is well recognized that estradiol is a potent regulator of GnRH release from the hypothalamus, the mechanism of this regulation is unknown. Physiologic studies have indicated that estradiol can increase, decrease, or not change GnRH secretion from the hypothalamus (1–4). Apparent contradictions in these studies may be explained by different effects of gonadal steroids on hypothalamic GnRH release, depending on the duration and dosage of hormone exposure, on the method used to measure GnRH secretion, or perhaps on species differences in GnRH regulation.
Published Version
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