Characterization and validation of ion mobility spectrometry in methamphetamine clandestine laboratory remediation

Abstract

This project evaluated the efficacy of ion mobility spectrometry (IMS) as a tool for determining remediation success at clandestine methamphetamine laboratory sites. Specifically, limits of detection (LOD), limits of quantitation (LOQ), and matrix effects were investigated as relevant to typical remediation sites and situations. The recoveries of pseudoephedrine and methamphetamine from a range of various surfaces likely to be found in a clandestine laboratory were examined. Portable IMS instruments with thermal desorption were found to be a reliable tool for evaluating the degree of remediation if sufficient procedural and instrumental controls are put into place. In general, detection limits were in the same range as state guidelines as well as laboratory methods using GC/MS and LC/MS. Direct vapor sampling can be used to detect high levels of methamphetamine and potential interferences, but cannot approach the detection limits needed for evaluation of remediation efforts. IMS cannot be used alone to determine the efficacy of remediation efforts; final confirmation using laboratory instrumentation is essential. For the purpose of this study, typical field settings of the IMS were used and the conditions were not optimized.