Abstract
Objective: Clindamycin is the drug of choice for the treatment of severe form of skin, soft tissue, and blood infections caused by resistant Staphylococcus aureus in the form of methicillin-resistant S. aureus (MRSA) and erythromycin-resistant S. aureus. In this research, we determine the susceptibility pattern of isolated S. aureus strains against antibiotics and the prevalence of resistant S. aureus in the form of MRSA, inducible clindamycin-resistant S. aureus (inducible macrolide-lincosamide-streptogramin B [iMLSB]) and constitutive clindamycin-resistant S. aureus (cMLSB).
 Methods: A total of 310 isolated S. aureus among 2000 different clinical samples were subjected to oxacillin (1 μg) as per the Kirby-Bauer disk diffusion method for MRSA. Clindamycin-resistant either in the form of iMLSB or cMLSB was determined through double disk diffusion method or D-test by use erythromycin (2 μg) and clindamycin (15 μg) as per the CLSI guidelines.
 Results: Out of total S. aureus, MRSA and methicillin-sensitive S. aureus (MSSA) were 78.06% and 20.64%, respectively. This study showed that iMLSB and cMLSB were 34.19% and 23.22%. Both iMLSB and cMLSB were found more among MRSA than MSSA (43.80%, 26.85% and 40.62%, 10.93%), respectively.
 Conclusion: This study helps for the characterization of different resistant strains of S. aureus along with the determination of the prevalence rate of these mutant forms causing nosocomial infections.
Highlights
Staphylococcus aureus is recognized as the causative agent of skin, soft tissue, and systemic infection
The increase of resistant staphylococcal infection with methicillin-resistant S. aureus (MRSA) has led to renewed interest in the use of macrolide-lincosamide-streptogramin B (MLSB) antibiotics for the treatment of such infections [5]
MRSA was identified by the oxacillin disk diffusion method
Summary
Staphylococcus aureus is recognized as the causative agent of skin, soft tissue, and systemic infection It frequently associated with the pus formation in different body sites infections. It is more common nosocomial as well as opportunistic pathogens [1]. The increase of resistant staphylococcal infection with MRSA has led to renewed interest in the use of macrolide-lincosamide-streptogramin B (MLSB) antibiotics for the treatment of such infections [5]. These family MLSB antibiotics with clindamycin are the preferred antibiotic due to its best pharmacokinetics property [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
