Abstract
The carcinoembryonic antigen (CEA) of a patient with squamous cell carcinoma of the cervix whose plasma CEA titer was 28 μg/ml and tumor CEA concentration was 900 μg/g was subjected to immunological and physicochemical analyses. By means of immunodiffusion and immunoelectrophoresis, cervical cancer CEA was found to be immunologically identical to colonic cancer CEA. However, cervical cancer CEA appeared in gel filtration to be 370,000 in molecular size, thus being appreciably larger than the 200,000 size CEA usually found in colonic carcinomas. The CEA in this squamous cell carcinoma of the cervix was localized by an immunoperoxidase reaction performed on paraffin sections of the tumor and was found to be almost exclusively present on the surface of the tumor cells. It appears that this immunocytochemical procedure for CEA detection and localization can be employed in the routine histopathological evaluation of such neoplastic tissues.
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