Abstract

 
 
 
 Purpose: To evaluate the characteristics and biodistribution of trans resveratrol-PEG-folic acid-gold nanoparticle conjugates (rsv-PEG-FA-AuNP).
 Methods: Gold nanoparticles were produced by citric reduction followed by conjugation of PEG-folic acid and resveratrol. Characterization of rsv-PEG-FA-AuNP conjugates including their particle size, zeta potential, and by Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) was carried out. Biodistribution study of rsv-PEG-FA-AuNP was carried out using female Sprague Dawley rats. Biodistribution data were obtained from high performance liquid chromatography (HPLC) analysis.
 Results: The mean particle size and zeta potential of rsv-PEG-FA-AuNP were 249.03 ± 10.31 and - 36.33 ± 3.12 mV, respectively. TEM images showed rsv-PEG-FA-AuNP conjugates formed spherical shape. Rsv-PEG-FA-AuNP conjugates found in plasma, kidney (1.90 ± 0.20 μg/g), spleen (2.65 ± 1.18 μg/g), liver (1.74 ± 0.03 μg/g), and lung (1.82 ± 0.12 μg/g), after 90 minutes intravenous administration (i.v.) in female Sprague Dawley rats. No free resveratrol was found in plasma, kidney, or spleen after i.v administration in female dawdle Sprague Dawley rats.
 Conclusion: Resveratrol-PEG-FA-AuNP conjugates appear to be a potential chemotherapy delivery system for active targeting purposes because of its longer systemic circulation and its accumulation in the kidney.
 
 
 
Highlights
Gold nanoparticles are a potential device for drug delivery applications, especially in chemotherapy
The rsv-PEG-FA-AuNP conjugates increased in size and polydispersity index almost five times as much as gold nanoparticles (Table 1)
Gold nanoparticles modified by PEG and folic acid conjugates are potentially suitable drug carriers for resveratrol, a potential chemotherapy substance
Summary
Gold nanoparticles are a potential device for drug delivery applications, especially in chemotherapy. Overexpression of folate receptor had been exploited for active targeting purposes. Folate receptors are highly overexpressed on the Resveratrol, a polyphenol compound, is found in grapes, peanuts, and melinjo [3]. Its potential as an anticancer drug is based on its progressive action as anti-initiation, anti-promotion, and antiprogression of the carcinogen [4]. It has been seen as an anticancer agent in a wide range of human cancers: breast, bladder, blood, bone, brain, cervical, colon, esophageal, eye, gastric, head and neck, kidney, liver, lung, ovarian, prostate, skin, thyroid, uterine l. The natural occurrence and low cost of resveratrol is a reason that it is promising for further anticancer research [5]
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