Abstract
Bioactivity and biocompatibility are crucial for tissue engineering scaffolds. In this study, hydroxyapatite (HAP) was incorporated into polyetheretherketone/polyglycolicacid (PEEK/PGA) hybrid to improve its biological properties, and the composite scaffolds were developed via selective laser sintering (SLS). The effects of HAP on physical and chemical properties of the composite scaffolds were investigated. The results demonstrated that HAP particles were distributed evenly in PEEK/PGA matrix when its content was no more than 10 wt %. Furthermore, the apatite-forming ability became better with increasing HAP content after immersing in simulated body fluid (SBF). Meanwhile, the composite scaffolds presented a greater degree of cell attachment and proliferation than PEEK/PGA scaffolds. These results highlighted the potential of (PEEK/PGA)-HAP scaffolds for tissue regeneration.
Highlights
Polyetheretherketone (PEEK), as an attractive scaffold biomaterial, possesses excellent mechanical characteristics, great thermal stability, as well as good processability [1,2,3], while bioinertness and slow degradability inhibit its further application [4,5]
These results indicated that the incorporation of particles into the matrix would stimulate and that the incorporation of HAP particles into the PEEK/PGA
Appeared some cell fusion (Figure 10B5). These results further demonstrated that the scaffolds with
Summary
Polyetheretherketone (PEEK), as an attractive scaffold biomaterial, possesses excellent mechanical characteristics, great thermal stability, as well as good processability [1,2,3], while bioinertness and slow degradability inhibit its further application [4,5]. Its unsolved problem is a lack of the natural cell adjusting PGA content. Lee properties, bone-bonding ability, preeminent biocompatibility bioactivity [11,12,13]. PLGA/Gelatin/HAP scaffolds via and an electrospinning method and found al. Raafat et al. HAP into the scaffolds led to an encouraging improvement in bioactivity [15]. HAP-(starch/N-vinylpyrrolidone) composites using γ-radiation-induced graft and copolymerization and confirmed that these composites were both bioactive andcopolymerization biocompatible [16]. Incorporation of HAP into PEEK/PGA hybrid has laid a particular basis for. PEEK/PGA(PEEK/PGA)-HAP hybrid has laid ascaffolds particular basis for enhancing scaffold biocompatibility containing enhancing the scaffold andselective bioactivity. Scaffolds different content of HAPbiocompatibility were prepared via laser(PEEK/PGA)-HAP sintering (SLS) systems. The effects of on apatite-forming ability were evaluated after soaking into simulated body fluid (SBF). Characteristics and MG-63 cells responses of scaffolds were investigated
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