Characterization and assessment of compression and compactibility of novel spray-dried, co-processed bio-based polymer

Abstract

Co-processed spray-dried excipients prepared of Buchanania lanzan seed polysaccharides with mannitol, lactose, and silicon dioxide in ratios of (1:1, 1:2, and 2:1), were developed into tablets form by direct compression and characterized. The semi-amorphous nature and physical interaction between co-processed excipients were confirmed by X-ray diffraction, and infrared spectroscopy. Morphological study showed an altered rough surface. Thermogravimetric analysis demonstrated stability up to 200 °C, followed by depolymerization. Packability analysis revealed reduced cohesiveness, with improved flowability for co-processed silicon dioxide (2:1) (a: 0.351). The results of Kuno's constant suggested better packability for co-processed silicon dioxide (1:1) (k’: 2.19) and mannitol (1:2) (k’: 1.71) than lactose (2:1) (k’:1.24). The results of compressibility revealed that the co-processed silicon dioxide 1:2 and 2:1 tablets presented initial fragmentation followed by plastic deformation with Py: 7.97 and Py: 11.57, respectively. In addition, compression susceptibility and maximum tensile strength obtained from Leuenberger analysis showed that the maximum crushing strength for co-processed lactose (1:1, 1:2, and 2:1) and mannitol (2:1) tables were attained at lower compression pressures. Cytotoxicity against Caco-2 and HeK 293 cells exhibited >98% of cell viability. The findings demonstrate that co-processed polysaccharides could be further explored as an effective alternative for directly compressible excipient.