Abstract
Twenty-four oxidovanadium(IV,V) complexes with tridentate Schiff base ligands based on 5-nitrosalicylaldehyde, 5-methoxysalicylaldehyde, or 5-sulfosalicylaldehyde and respective hydrazide were isolated, and characterized using physicochemical and spectroscopic methods. Three of them were structurally characterized by single-crystal X-ray structure determination. The biological activity studies included inhibition of human tyrosine phosphatases, studies on myocyte C2C12, adipocyte 3T3-L1, and human hepatocyte HepG2 cell lines, glucose uptake in myocytes and adipocytes, and cytotoxicity tests. The complexes that were unstable in solutions showed biological activity typical of other V(IV) complexes, while the stable one showed much higher, ligand-dependent, activity.
Highlights
Vanadium compounds are of great importance in science and in industry, including the very popular V2O5 used as a catalyst [1,2,3]
Its variety of oxidation states, coordination numbers, and biological activity result in frequent use of this metal in coordination chemistry, especially because vanadium in different oxidation states forms a range of stable compounds, making synthesis relatively simple
In the course of our investigation connected with the insulin-mimetic properties of vanadium compounds, it is worth noting that both inorganic complexes and those with organic ligands are found to be active
Summary
Vanadium compounds are of great importance in science and in industry, including the very popular V2O5 used as a catalyst [1,2,3]. After 48 h of incubation of 3T3-L1 adipocytes, medium was changed for standard medium with human recombinant insulin and tested vanadium complexes. Incubations of vanadium complexes with cells were performed in triplicate, and each compound was tested in three to four independent experiments.
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