Abstract
Novel nanocomposite films consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), titanium dioxide (TiO₂), and silver (Ag) nanoparticles were prepared containing various amounts of TiO₂ and Ag nanoparticles. The effects of composition and TiO₂ nanoparticles on the physico-chemical properties of nanocomposite samples were evaluated by X-ray diffraction and infrared analysis. The greatest swellings were observed in the acidic pH. GC/PEG/TiO₂/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. These nanocomposites were shown to have antibacterial activity towards Escherichia coli. GC/PEG/TiO2/Ag composite films had higher antimicrobial activities than GC/PEG and GC/PEG/TiO₂ nanocomposite films. GC/PEG/TiO₂/Ag composite films have potential application as wound dressings.
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