Characterization and Antibacterial Evaluation of New Complexes of Nicotinamide semicarbazon Manganese (II), Zinc (II), Silver (I) Synthesizes

Abstract

The purpose of this research article is to explore the coordination chemistry and antibacterial activity of six new mononuclear complexes formed via reacting Ag(I), Zn(II), and Mn(II) ions with the Schiff base as a ligand (Nicotinamide- semicarbazone) in a (1:2) ratio in both acidic and basic medium., the six complexes are characterized by elemental analysis(CHN), atomic absorption spectroscopy, Infrared spectroscopy, (1H NMR). and different Technique such as melting point, conductivity measurements, Molar refraction The suggested formula of the complexes were [M(NASC)2] Xn in natural medium and [M(NASC)2] in basic medium, M = Ag n=1, M= Zn, Mn n=2, X=NO3 NASC = Nicotinamide- semicarbazone. It was a tridentate ligand it coordinated onto metal ions via three nitrogen atoms, producing off white or yellow complexes with only an octahedral geometry. These complexes and their ligands were evaluated as antibiotics against a series of medically significant bacteria, and both were found to be very effective.