Abstract
This work demonstrates a simple and feasible approach for the synthesis of silver nanoparticles (AgNPs) in water with a high molecular weight (MW) exopolysaccharide fraction, EPS1 produced by a medicinal fungus Cs-HK1. The formation and properties of AgNPs were evaluated at various temperatures, time periods, and silver nitrate/EPS1 concentrations in water. At suitable conditions (100 °C, 60 min and 10 mM AgNO3 with 1.0 mg/mL EPS1), AgNPs were formed with an average diameter of 50 nm and a narrow size distribution, remaining as a stable dispersion for at least 2 months. EPS1 may be acting as a reducing and stabilizing agent for the formation of AgNPs, which were attached to the hydroxyl groups of EPS1. The AgNPs formed in EPS1 solution exhibited a concentration-dependent inhibition of both Gram-negative and -positive bacteria but a very low cytotoxicity on the RAW264.7 murine macrophage cells. The results demonstrated the feasibility for green synthesis of AgNPs as potential antibacterial agents using natural polysaccharides dissolved in water.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
