Abstract
This study was aimed to investigate the cerebroprotective potential of methanolic stem extract of Colebrookea oppositifolia (MsCO). The MsCO was evaluated against global ischemia and reperfusion (I/R) induced brain injury in Wistar rats. In the outcomes, the I/R insult caused significant deterioration of neurological (p<0.01), cognitive (p<0.01), and motor functions (p<0.01), along with significant alterations in the antioxidant parameters (decreased SOD and catalase enzyme activities, along with derease in GSH and increase in LPO; p<0.01 for all parameters), morphology (cerebral edema and infarct area) (p<0.01) and histology of the brain tissue in the I/R control group compared to normal control. Interestingly, the MsCO (200 and 400 mg/kg) pretreatment for seven days has attenuated all the I/R-induced alterations significantly and dose-dependently compared to I/R control group. Moreover, the LC-MS/MS analysis of MsCO revealed the presence of Acteoside, Pentagalloyl glucose, and Quercetin as major phytoconstituents. Based on these outcomes we conclude that MsCO possesses potent cerebroprotective activity against ischemia-reperfusion-induced brain injury in Wistar rats.
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