Abstract
BackgroundInfectious bronchitis is a severe disease caused by infectious bronchitis virus (IBV) that affects fowl flocks worldwide. The understanding of the mechanisms involved in IBV evolution and variation would provide important theoretical basis for prevention and control of the disease in the future.MethodsIBV strain GD was isolated from southern China in 2013 and the complete genome sequencing and phylogenetic analysis were performed.ResultsThe genome of approximately 27,680 nt comprised six genes, with insertions and mutations in most of the structural genes. The S1 gene showed the highest identity to strain TW2575/98 isolated in Taiwan, and was distantly related to the H120 vaccine strain. Phylogenetic analysis showed that the S1 gene of strain GD was also related to that of TW-type strains. Recombination analysis indicated that strain GD was a chimera whose putative parental strains belonged to the QX- and TW-type subgroups.ConclusionsAn increasing number of TW-type strains have been isolated from China in recent years, which is in agreement with our findings, suggesting the emergence and increased prevalence of new TW-type strains in southern China.
Highlights
Infectious bronchitis is a severe disease caused by infectious bronchitis virus (IBV) that affects fowl flocks worldwide
The results showed that GD strain was clustered in different classification based on the phylogenetic analysis of different genes, indicating that recombination events might occur between the S1 gene and other genes (Fig. 2c–f )
Phylogenetic, and recombination analysis were performed to explore the genetic features of this new epidemic isolate, alongside analysis of TW-type strains isolated in mainland China
Summary
Infectious bronchitis is a severe disease caused by infectious bronchitis virus (IBV) that affects fowl flocks worldwide. An increasing number of new serotypes or variants of IBV caused by frequent gene mutation have become the major challenge of the prevention and control of IB [9]. Genomic recombination has been shown to occur at high frequency in coronaviruses, IBV [14,15,16,17], potentially leading to outbreaks of disease. All of these findings suggest the importance in the investigation of new and emerging IBV isolates
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