Abstract
Different shapes and sizes of water-soluble mannitol (MAN) particles were prepared using a supercritical assisted atomization (SAA) process. The needle-shaped and spheroidal mannitol particles were prepared using water and aqueous ethanol, respectively, as solvent of the MAN solution. The size of mannitol particles increased with increasing the concentrations of MAN solution and deceased with increasing saturator temperatures and CO2-solution flow ratios. The in vitro aerodynamic behavior of the mannitol particles as dry powder inhaler (DPI) formulations was investigated using an Andersen cascade impactor. The effects of the morphology and the size of mannitol particle on powder deagglomeration and flowability were evaluated. In vitro aerosolization tests showed that the spheroidal particles favor deagglomeration of mannitol powder and the fine particle fraction (FPF) was enhanced by the excellent powder flowability of the larger mannitol microparticles.
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