Abstract
Objectives: access the white-matter hypointensity (WMHypo) volume characteristics in relationships with age. Methods: Analysing for volumes of cerebral WMHypo volumes from cranial magnetic resonance images taken from 455 normal cognitive Vietnamese subjects (males 47,03%), and ranging in age from 17 to 87 years. Results: The volumes of WMHypo were increasing with age in both male (p< 0,001) and female (p < 0,001). And regression analyses indicated that WMHypo volume increasing in cubic manners that relatively stable with age under 40-50 y.o then sharply increase from 60s. Conclusion: White matter hypointensity had appeared since youth and boosted from middle age, since any cognitive impairment could be detected as in elders, and and its growth rate coexists with atrophy in the cerebral degeneration process such as Alzheimer and Parkinson diseases.
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