Abstract
Using the cannula-inserting method, vascular responses to endothelin-1 were investigated in the isolated and perfused simian digital artery. Endothelin-1 produced a strong and sustained vasoconstriction with EC50 of 5.15 +/- 1.24 ng. The endothelin-1-induced vasoconstriction was significantly inhibited in the Ca(++)-removed perfusate. It was partly attenuated by diltiazem, a potent Ca++ entry blocker, but not affected by alpha-adrenoceptor antagonist phentolamine, indicating that endothelin-1 causes vasoconstriction by either the extracellular Ca++ entry or intracellular movement of Ca++ from the cytosolic storage site. From these results, it is suspected that ET-1 is partially related to skin circulatory disturbances such as Raynaud's phenomenon.
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